CancerTreatmentSpecialtyClinic-HIBIYA UCHISAIWAICHO Clinic

What’s immunotherapy?

Our body is composed of about 60 trillion cells and it’s said that around 5,0000 cancer cells are also created even healthy people through new cells replace old cells everyday. But immune cells, such as lymphocytes monitor and destroy cancer cells. So, it’s also said that healthy people doesn’t fall cancer thanks to immune cells those attack cancer cell and destroy, however, cancer patient fall cancer due to weakening of immune cell activity.

Cellular immunotherapy is a treatment by heightening your own immune cell activity, then attacking and destroying cancer cells.

Cellular immunotherapy is still new remedy, around 20 years since study was started, however, this is also gaining big attention such as being permitted as advanced medical care at some university hospitals at present. Further, you can also expect synergistic effect by combining with so called 3 major treatments (“Surgical treatment”, “Chemotherapy” and “Radiation therapy”)

Cellular immunotherapy has NO physical problem and severe side effect because of curing cancer by utilizing your own immunity, not curing by external power like traditional treatments.

Maintaining and enhancing Quality of Life (QOL) of patient him/herself will be needed for future cancer treatment.. In this view, we expect that Ccellular immunotherapy” , which has no physical & mental issue and has very little side effect concern, will attract attention more and more.

Our clinic offer 2 kinds of Cellular immunotherapies

Highly activated NK cell
therapy

blood collection

Cellular immunotherapy gains attentions as no side effect concern treatment, among those, Highly activated NK cell therapy gains the highest attention.
NK cell = Natural Killer cell
One of kinds of immune cells, it doesn’t have a antigen and antibody response*, weak point, and those immune cells initially attack abnormal cells.
Those immune cells such as T-lymphocyte, B cells also attack against abnormal cells, however, those activity is constrained due to antigen and antibody response*
NK cells are not dominated by antigen and antibody response, therefore, no activity constraint exists, work freely and flexibly, then attack cancer cells.
Highly activated NK cell therapy is to fight against cancer cells by increasing the number of NK cells.
*antigen and antibody response…means only attacks against those objects, which were recognized as abnormal cells previously.

The features of Highly activated
NK cell therapy

  • NK cell has no antigen and antibody response, and is supe
    rior among immune cells, which attack cancer cells.
  • No side effect concern
  • Reasonable (natural) and continuous treatment and quality
    of life (QOL) can be kept at high level.
  • Effective for prevention of recurrence and spread
  • Possible synergistic effect.

Compound cellular
immunotherapy

Dendritic activate killer Tlymphocyte

Those immunotherapies directly attack cancer cells at last are mainly NK cell and cytotoxic T lymphocyte (CTL).

Our clinic has executed highly activated NK cell based on research supported by scientific logic and ground.
As a result of promoting further research at cell culture facility and application to clinical medicine, we established multiplication and culturing methodology of cytotoxic T lymphocyte (CTL) by utilizing and leading dendritic cell (DC).
Compound cellular immunotherapy is a combined therapy of dendritic cell therapy, which leads cytotoxic T lymphocyte and in vivo, DAK (Dendritic activate killer T lymphocyte therapy), which attacks cancer cell by returning cultured cytotoxic T lymphocyte (CTL) into vivo, with cellular therapy as its centering.
Our clinic offers not only body-friendly cancer therapy, but effective
and forefront cellular immunotherapy.

The features of Compound
cellular immunotherapy

  • 3 kinds of cellular immunotherapy is available by one time
    blood collection
  • No side effect concern
  • Reasonable (natural) and continuous treatment and quality
    of life (QOL) can be kept at high level.
  • Possible synergistic effect.

Case introduction

Lesion was spread variously to whole lung.

However, node was almost destroyed by combination of both anti-cancer drug and highly activated NK cell therapy.
Highly activated NK cell therapy could be completed.

She was diagnosed as “lung cancer “(pulmonary adenocarcinoma) in July 2009. Due to having various node in whole lung, operation and radiation therapy were not applicable.
She started to take highly activated NK cell therapy with anti-cancer drug since August 2009. CYFRA figure was 5.6 at that time.
After 3 times of highly activated NK cell therapy medication, the main tumor started to be shrink trend and multiple pulmonary nodule was gradually vanished. Then, tumor marker after 5th medication, CYFRA went down to normal level or 1.0, after 11th medication, it also went down to 0.5, after 12th medication, main tumor was completely destroyed and multiple pulmonary nodule was nearly perfectly vanished.
As of February 2010, she completed highly activated NK cell therapy, continues anti-cancer drug only.

Case 3 Pancreatic cancer -> Spread to liver, lung and pleura

Spread to liver etc was destroyed by combination of highly activated NK cell
therapy and anti-cancer drug.
Outcome after therapy was good and she could return to work.

She had subjective symptom such as hypogastrium pain, distention of abdomen, chest compression etc. since beginning of December, 20008 or around. As result of detailed examination, during year end to beginning of the year, she was diagnosed as pancreatic cancer (pancreas tail) and spread to liver, lung and pleura, therefore, she started anti-cancer drug medication.
Tumor marker (CA19-9) went up to 318,417 as of January 21st, then, she started to take highly activated NK cell therapy since beginning of February.
As of February 12th or the timing of 1st medication of highly activated NK cell therapy, the figure went to down to 7,355.
As of 4th medication of highly activated NK cell therapy, the figure went to down to 141 and other tumor marker (CEA and CA125) also continuously went down steadily.
Spread to liver and bronchi & lung lymph node was destroyed and pancreatic cancer also became vanishing trend according to CT photograph in early May.

Case 4 Pancreatic cancer

After operation of pancreatic cancer and anti-cancer drug medication started once, however, spread to liver was found.
3 months after starting highly activated NK cell therapy, tumor was destroyed or reduced and tumor marker also became into

He was diagnosed as pancreatic cancer (pancreas body), then took operation in December 2006. After operation, anti-cancer drug (Gemzar) medication was taken for 6 times till June 2007, however, spread to liver was found by follow up CT in October 2007. He was announced that life expectancy is 6 months to 1 year.
He started to take highly activated NK cell therapy with anti-cancer drug at home doctor since November 2007.
Highly activated NK cell therapy was taken for him 1 term (6 times medication) & every other week. Also, combination of TS1 and Gemzar for anti cancer drug was taken too. When he takes CT examination and tumor marker examination in Mid February, 2008, 2 out of tumors, which spread to liver were destroyed and another one was also confirmed as shrinking. Further, his tumor marker (CA19-9) was drastically went down from 5,171, before starting treatment, to 28, normal figure, after 1 term finished.

Case 4 Rectal cancer -> Spread to liver (Liver cancer)

After operation of rectal cancer, spread of 25 places in liver was found.
Small metastatic lesions were destroyed and the biggest metastatic lesion was also almost destroyed by combination of highly

He was diagnosed as rectal cancer (Stage IV) in May 2008, then took extirpation. In next month, 25 places of multiple liver metastasis (liver cancer) were found by CT examination
He started t take highly activated NK cell therapy since July 2008 with taking medication by anti cancer drug by home doctor since June.
CT examination was taken again at the timing of 7th medication of anti cancer drug and 5th medication of highly activated NK cell therapy. The biggest tumor, which spread to liver became a bit smaller with unclear boundary, and 2 small tumors, which could be seen clearly were almost destroyed.
Another CT examination was taken again at the timing of 12th medication of anti cancer drug and 10h medication of highly activated NK cell therapy. The biggest tumor shrunk to one-third and 2 small tumors were destroyed completely.
The remnant of tumor was almost destroyed by 21 times medication of anti cancer drug and 20times medication of highly activated NK cell therapy. Also, his weight increased as well.

Clinic introduction

Director :Masayoshi UH
Facilities introduction

Director :Masayoshi UH (1959, M)
A member of Japan Surgery Scientific Society, Certified physician by Japan Surgery Scientific Society

【History】
1987 Graduated Gunma University, Faculty of medicine
1988 2nd Surgery section, Tokyo Medical and Dental University, Faculty of Medicine Hospital
1989 Anesthesiology, Musashino Red Cross Hospital
1993 Thoracic cardiovascular surgery, Tokyo Municipal Bokuto Hospital
1995 2nd Surgery Section, Tokyo Medical and Dental University, Faculty of Medicine Hospital
2005 HIBIYA UCHIWASAIWAICHO Clinic

Doctor: Tatsuaki ISHIGURO

Doctor: Tatsuaki ISHIGURO (1961, M)
D.M.
A member of Japan Surgery Scientific Society,
Certified physician by Japan Surgery Scientific Society

【History】
1987  Graduated Tokyo University, Faculty of Medicine
1995  Graduated Tokyo University, Faculty of Medicine Graduate School
1997  Assistant at 1st Surgery Section of Tokyo University
2005  The University of Texas MD Anderson Cancer Center Visiting Associate Professor
2008  HIBIYA UCHISAIWAICHO Clinic (Available on Mon, Wed)

Doctor: Keiko MATSUURA (1966, F)
D.M.
Board-certified Chinese Medicine Specialist
Board-certified Hematologist
Board-certified Pediatrician

【History】
1994 Graduated Tokyo Medical University, Faculty of medicine
1998 Completed Tokyo Medical University Graduate School
1998 Assistant teacher of Pediatrics at Tokyo Medical University Hospital
2008 Assistant teacher at KEIO University Hospital Chinese Medicine Center
2010 Specially appointed lecturer at KEIO University Chinese Medicine Center
2014 Part-time lecturer at Oriental Medicine Division of Regional Medicine Center of Jichi Medical University Hospital
2015 HIBIYA UCHISAIWAICHO Clinic (Available on Fri)

Treatment flow

1. Booking for first examination

Prior booking is necessary for examination. So, please make an appointment first even consultation by family only.

Toll Free: 0120-982-809
Telephone from the foreign countries :+81-3-5510-9050

Telephone

2. First examination

Logical background and achievement of the therapy are guided. Also, proceeding of treatment, schedule, cost etc., are also be precisely guided as well.
  Treatment will be started after understanding of all and consent with patient & his/her family.

docter

3. Blood collection

30cc~50cc blood is collected from patient for culturing NK cell.
Please be informed the quantity of collection may be increased by condition of patient.

Telephone

4. Culturing

Collected blood will be cultured and activated in special facility.

Telephone

5. Infusion

Highly activate NK cell will be returned to body of patient by infusion. Total time for infusion is around 60 minutes.

Telephone

6.

Reviewing result & future of cancer treatment and consultation between doctor and patient or his/her family at the timing of end of 1st term.

Telephone

Our clinic sets 6 times (Blood collection & infusion)as 1 term

Normal cancer treatment

Intensified cancer treatment

* Cancer treatment schedule may be varied by patient.
Schedule shown above is just model case of both normal and intensified cancer treatment.

Treatment Cost

Highly activated NK cell
therapy

6th times (1 term)

1,879,200JPY

(Local VAT included)

※Term means 2 times of drip infusion of matured dendritic cell (DC) injection for 2 times + highly activated NK cell drip infusion for 4 times + Dendritic activate killer T lymphocyte therapy (DAK) drip infusion for 2 times.

※Please pay expense for therapy by transfer by day of blood collection.
It will be needed for fixing schedule of culturing engineer, prepare formulation required for
culturing. Your understanding is appreciated

※Expense for therapy includes all cost for compound cellular immunotherapy
【 Blood component fee by apheresis system, technical fee for cell processing, follow up
examination fee and other blood inspection fee etc. 】

Compound cellular
immunotherapy

8th times (1 term)

2,494,200JPY

(Local VAT included)

※Term means 2 times of drip infusion of matured dendritic cell (DC) injection for 2 times + highly activated NK cell drip infusion for 4 times + Dendritic activate killer T lymphocyte therapy (DAK) drip infusion for 2 times.

※Please pay expense for therapy by transfer by day of blood collection.
It will be needed for fixing schedule of culturing engineer, prepare formulation required for
culturing. Your understanding is appreciated

※Expense for therapy includes all cost for compound cellular immunotherapy
【 Blood component fee by apheresis system, technical fee for cell processing, follow up
examination fee and other blood inspection fee etc. 】

Contact us

billding image

Address
Shinbashi MM Building 3F, 1-18-14 Shinbashi, Minato-ku, Tokyo, 1050004, Japan

Mail: info@hu-clinic.com